Peter Farrelly

Director

Chris Rock

Osmosis Jones (voice)

Laurence Fishburne

Thrax (voice)

David Hyde Pierce

Drix (voice)

Brandy Norwood

Leah (voice)

William Shatner

Mayor Phlegmming (voice)

Ron Howard

Tom Colonic (voice)

Kid Rock

Kidney Rock (voice)

Bill Murray

Frank Detorre

Molly Shannon

Mrs. Boyd

Chris Elliott

Bob