Alfred L. Werker

Director

Basil Rathbone

Sherlock Holmes

Nigel Bruce

Dr. Watson

Ida Lupino

Ann Brandon

Alan Marshal

Jerrold Hunter

Terry Kilburn

Billy

George Zucco

Professor Moriarty

Henry Stephenson

Sir Ronald Ramsgate

E. E. Clive

Inspector Bristol

Arthur Hohl

Henchman Bassick

May Beatty

Mrs. Jameson, Brandon Housekeeper